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Evaluation of serum miR‐191‐5p, miR‐24‐3p, miR‐128‐3p, and miR‐376c‐3 in multiple sclerosis patients
Author(s) -
Vistbakka J.,
Sumelahti M.L.,
Lehtimäki T.,
Elovaara I.,
Hagman S.
Publication year - 2018
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12921
Subject(s) - multiple sclerosis , microrna , medicine , disease , oncology , immunology , gene , biology , genetics
Background Biomarkers that could be used in early diagnosis of multiple sclerosis ( MS ), segregation of disease subtypes, and discrimination of the aggressive disease course from the benign one are urgently needed. Objective The aim of this study was to investigate the specificity of circulating micro RNA s: miR‐191‐5p, miR‐128‐3p, miR‐24‐3p, and miR‐376c‐3p in MS and evaluate their association with disease activity and disability progression. Methods The expressions of circulating mi RNA s were studied in serum of 100 subjects (53 relapsing‐remitting ( RRMS ), 20 primary progressive ( PPMS ), and 27 controls), using miScript serum mi RNA RT ‐ PCR assay techniques. Results In comparison with controls, miR‐191‐5p and miR‐24‐3p were overexpressed in RRMS and PPMS , with no differences between the subtypes. miR‐24‐3p correlated positively with the disability progression index in the combined group of all patients with MS . miR‐128‐3p showed tendency toward the predominant expression in PPMS and correlated positively with the annual relapse rate in RRMS . miR‐376c‐3p expression levels did not differ between the groups, and no associations were found to clinical parameters. Conclusion This study highlighted the connection of circulating mi RNA s to MS . miR‐24‐3p and miR‐128‐3p showed a tendency of association with disability accumulation and disease activity, respectively. Further studies should evaluate their suitability for clinical use.