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Vaccines and multiple sclerosis
Author(s) -
Frederiksen J. L.,
Topsøe Mailand M.
Publication year - 2017
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12837
Subject(s) - multiple sclerosis , medicine , vaccination , optic neuritis , pediatrics , immunology
An association between certain vaccinations and onset or relapse of multiple sclerosis ( MS ) has been debated. Based on PubMed, we made a thorough literature review and included all relevant studies, 51 on MS and 15 on optic neuritis ( ON ). Case studies were excluded. With the exception of a live vaccine against yellow fever, vaccinations appear safe in untreated patients with MS and ON . However, most studies were underpowered, and small risks cannot be excluded. One study of BCG vaccination after the first demyelinating event showed even a reduced risk of developing MS . Further studies are needed to fully exclude a causal association.