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Wake‐up stroke—Amendable for thrombolysis‐like stroke with known onset time?
Author(s) -
Kurz M. W.,
Advani R.,
Behzadi G. N.,
Eldøen G.,
Farbu E.,
Kurz K. D.
Publication year - 2017
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12686
Subject(s) - thrombolysis , medicine , stroke (engine) , pathophysiology , ischemic stroke , cardiology , intensive care medicine , ischemia , myocardial infarction , engineering , mechanical engineering
Patients suffering an acute ischemic stroke can be treated with intravenous thrombolysis in the absence of contraindications. A known onset time is a prerequisite as treatment, according to guidelines, has to be started within 4.5 hours. In patients awakening with a stroke, the last time they were seen without a neurological deficit is assumed to be the time of onset. Thus, despite of lack of contraindications on initial brain imaging, these patients are largely excluded from therapy. This review discusses the underlying pathophysiological, clinical, and radiological evidence surrounding wake‐up stroke and its consequences for making treatment decisions.