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Upper motor neuron evaluation in multiple sclerosis patients treated with Sativex ®
Author(s) -
Carotenuto A.,
Iodice R.,
Petracca M.,
Inglese M.,
Cerillo I.,
Cocozza S.,
Saiote C.,
Brunetti A.,
Tedeschi E.,
Manganelli F.,
Orefice G.
Publication year - 2017
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12660
Subject(s) - spasticity , multiple sclerosis , upper motor neuron , modified ashworth scale , medicine , electrophysiology , expanded disability status scale , physical medicine and rehabilitation , physical therapy , amyotrophic lateral sclerosis , disease , psychiatry
Background Spasticity in multiple sclerosis (MS) results from an imbalance of inputs from descending pathways to the spinal motor circuits, as well as from a damage of the corticospinal tract (CST). Objectives To assess CST impairment in MS patients with and without spasticity and to evaluate its evolution under Sativex ® treatment. Methods Ten MS patients with spasticity (“cases”) underwent clinical (EDSS, 9‐hole Peg, Ashworth scale, Timed 25‐Foot Walk, and NRS for spasticity), MRI (CST fractional anisotropy [FA]), and electrophysiological (central motor conduction time [CMCT] and H/M ratio) evaluations at baseline and after 12 months. We selected 20 MS patients without spasticity as control group at baseline. Results At baseline, cases showed a lower CST FA (0.492±0.045 vs 0.543±0.047; P =.01) and a higher CMCT ( P =.001) compared to the control group. No correlations were found between clinical, electrophysiological, and MRI features. After 12 months, cases showed a decrease in non‐prevalent degree of impairment (PDI) side FA (0.502±0.023 vs 0.516±0.033; P =.01) without differences for electrophysiological features compared to baseline. Treatment with Sativex ® resulted in a reduction of NRS for spasticity ( P =.01). Conclusions We confirm the presence of CST impairment in MS patients with spasticity. We did not identify structural/electrophysiological correlates that could explain Sativex ® clinical effect.