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Cumulative evidence for MS as a neural network disconnection syndrome consistent with cognitive impairment mechanisms and the confounding role of fatigue and depression—outlook from the Fourth Nordic MS symposium
Author(s) -
EttingerVeenstra H.
Publication year - 2016
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12655
Subject(s) - disconnection , cognitive impairment , depression (economics) , psychology , neuroimaging , cognition , confounding , clinical psychology , neuroscience , psychiatry , medicine , political science , law , economics , macroeconomics
The Fourth Nordic MS symposium served as a platform to present an overview over the rise and impact of cognitive impairment in people with MS , from early stages on, impairing their quality of life. After discussing MS and cognitive impairment symptoms, a review on the pathophysiology underlying cognitive impairment was given, followed by a talk on neuroimaging highlighting cortical reorganization in MS ‐affected brains. As a conclusion, therapy and treatment options were discussed. The symposium presented several cutting‐edge research studies providing or testing working models that appear successful in predicting and explaining cognitive impairment in MS , such as the disconnection syndrome.