Cumulative evidence for MS as a neural network disconnection syndrome consistent with cognitive impairment mechanisms and the confounding role of fatigue and depression—outlook from the Fourth Nordic MS symposium

The Fourth Nordic MS symposium served as a platform to present an overview over the rise and impact of cognitive impairment in people with MS , from early stages on, impairing their quality of life. After discussing MS and cognitive impairment symptoms, a review on the pathophysiology underlying cognitive impairment was given, followed by a talk on neuroimaging highlighting cortical reorganization in MS ‐affected brains. As a conclusion, therapy and treatment options were discussed. The symposium presented several cutting‐edge research studies providing or testing working models that appear successful in predicting and explaining cognitive impairment in MS , such as the disconnection syndrome.