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Self‐reported levels of education and disability progression in multiple sclerosis
Author(s) -
D'hooghe M. B.,
Haentjens P.,
Van Remoortel A.,
De Keyser J.,
Nagels G.
Publication year - 2016
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12555
Subject(s) - multiple sclerosis , medicine , psychology , physical medicine and rehabilitation , gerontology , psychiatry
Objectives The purpose of our study is to investigate whether socioeconomic indicators such as education, financial concerns, employment, and living status are associated with disease progression in relapsing‐onset and progressive‐onset Multiple Sclerosis ( MS ). Materials and methods We performed a cross‐sectional survey among individuals with MS , registered by the Flemish MS society and included socioeconomic indicators. A Cox proportional hazard regression was performed with the time from MS onset and from birth to reach an ambulatory disability milestone corresponding to Expanded Disability Status Scale ( EDSS ) 6 (requiring a cane) as outcome measure, adjusted for gender, age at MS onset, and immunomodulatory treatment. Results Among the participants with relapsing‐onset MS , subjects reporting education for more than 12 years had a reduced risk of reaching EDSS 6 compared to subjects reporting education for less than 12 years [ HR from onset 0.68 (95% CI 0.49–0.95); HR from birth 0.71 (95% CI 0.51–0.99)]. In progressive‐onset MS , longer education was associated with an increased hazard to reach EDSS 6 [ HR from onset 1.25 (95% CI 0.91–1.70); HR from birth 1.39 (95% CI 1.02–1.90)]. Conclusions Our study shows an association of self‐reported levels of education with disability progression in MS , with the highest level being protective in relapsing‐onset MS .