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Serum mannose‐binding lectin levels after aneurysmal subarachnoid hemorrhage
Author(s) -
Cai J.Y.,
Sun J.,
Yu Z.Q.
Publication year - 2016
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12552
Subject(s) - medicine , mannan binding lectin , subarachnoid hemorrhage , univariate analysis , glasgow outcome scale , glasgow coma scale , multivariate analysis , receiver operating characteristic , gastroenterology , predictive value of tests , lectin , immunology , surgery
Background Mannose‐binding lectin ( MBL ) is a key molecule of complement system, which is activated after aneurysmal subarachnoid hemorrhage ( aSAH ). We investigated the association of serum MBL levels with injury severity and clinical outcomes among aSAH patients. Materials and methods Serum MBL levels were determined in 132 aSAH patients and 132 controls. We assessed the association of serum MBL levels with 6‐month mortality and unfavorable outcome (Glasgow Outcome Scale score, 1–3) and injury severity reflected by World Federation of Neurological Surgeons ( WFNS ) scores and modified Fisher scores. Factors found significant on univariate analysis were further tested on a multivariate model. Meantime, the prognostic predictive values were evaluated using a receiver operating curves analysis. Results Serum MBL levels were significantly higher in patients than in controls. Serum MBL levels were independently associated with WFNS scores and modified Fisher scores. MBL was identified as an independent prognostic predictor for 6‐month mortality and unfavorable outcome. Moreover, its predictive value was similar to those of WFNS scores and modified Fisher scores. Conclusions Elevated serum MBL concentrations are associated with injury severity and long‐term poor prognosis after aSAH .