Premium
Plasma thrombospondin‐1 and clinical outcomes in traumatic brain injury
Author(s) -
Wang J.L.,
Jin G.L.,
Yuan Z.G.,
Yu X.B.,
Li J.Q.,
Qiu T.L.,
Dai R.X.
Publication year - 2016
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12528
Subject(s) - glasgow coma scale , medicine , traumatic brain injury , biomarker , glasgow outcome scale , receiver operating characteristic , multivariate analysis , predictive value of tests , predictive value , surgery , psychiatry , biology , biochemistry
Objective Thrombospondin‐1 ( TSP ‐1) acts as an anti‐angiogenic factor, and its expression in rat brain is upregulated after intracerebral hemorrhage. The current study was designed to investigate the change of plasma TSP ‐1 levels and assess the prognostic predictive effect of plasma TSP ‐1 level and it is associated with head trauma severity in the patients with severe traumatic brain injury ( STBI ). Materials and methods The plasma TSP ‐1 levels of 134 patients and 134 healthy controls were measured using enzyme‐linked immunosorbent assay. The relationships between plasma TSP ‐1 levels and trauma severity reflected by Glasgow Coma Scale (GCS) scores as well as between plasma TSP ‐1 levels and short‐term and long‐term clinical outcomes were analyzed using multivariate analysis. Results Plasma TSP ‐1 levels were statistically significantly higher in patients than in healthy controls. The multivariate analysis demonstrated close association of TSP ‐1 with GCS scores and also identified TSP ‐1 as an independent predictor for 1‐week mortality, 6‐month mortality, and 6‐month unfavorable outcome. Plasma TSP ‐1 levels had high prognostic predictive value based on receiver operating characteristic curve. The difference between its prognostic predictive value and GCS scores was not statistically significant. Conclusions Plasma TSP ‐1 levels are elevated and are highly associated with head trauma severity and short‐term and long‐term outcomes of STBI . TSP ‐1 may be a good prognostic biomarker of STBI .