z-logo
Premium
Cerebral hemodynamics in orthostatic intolerance with normal head‐up tilt test
Author(s) -
Shin K. J.,
Kim S. E.,
Park K. M.,
Park J.,
Ha S. Y.,
Kim S. E.,
Kwon O.Y.
Publication year - 2016
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12516
Subject(s) - medicine , orthostatic intolerance , hemodynamics , tilt table test , cerebral blood flow , orthostatic vital signs , anesthesia , blood pressure , cerebral perfusion pressure , vascular resistance , cerebral autoregulation , transcranial doppler , heart rate , cardiology , autoregulation
Objectives Orthostatic hypotension (OH) and postural orthostatic tachycardia syndrome (POTS) are well‐known causes of orthostatic intolerance (OI). In addition, there are OI patients who are characterized by the symptoms of OI and lack of abnormal findings in head‐up tilt (HUT) test. The aim of this study was to determine the cerebral hemodynamic changes in HUT test of OI patients with normal HUT (OINH). Materials and methods Two hundred and sixty‐one OI patients and 50 healthy controls were enrolled in this study. All subjects underwent transcranial Doppler test while performing the HUT test. Forty‐five patients had OH, 33 patients had POTS, and 183 patients had OINH. Blood pressures, heart rate, cerebral blood flow velocities (CBFVs), end‐tidal carbon dioxide (ET‐PCO 2 ), cerebral critical closing pressure (CCP), cerebral perfusion pressure (CPP), and cerebral vascular resistance (CVR) were measured during HUT test. We compared the hemodynamic parameters of OINH with those of OH, POTS, and healthy controls. Results Reduced CBFVs, CPP, and ET‐PCO 2 and elevated CCP were observed in the HUT test of all four groups. CVR was reduced in three OI patients. The drops in systolic CBFV, CPP, and CVR of OINH patients were greater than those of healthy controls. The changes in parameters in the HUT test of OINH group were not different from those of OH and POTS groups except prominent decrements of CPP and CVR in OH group. Conclusion Our findings suggest that OINH is true OI sharing the common pathomechanism of OH and POTS.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here