Premium
Prognostic factors for glioblastoma patients – a clinical population‐based study
Author(s) -
Fekete B.,
Werlenius K.,
Örndal C.,
Rydenhag B.
Publication year - 2016
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12481
Subject(s) - medicine , radiation therapy , glioblastoma , population , retrospective cohort study , poisson regression , chemotherapy , surgery , biopsy , oncology , environmental health , cancer research
Objectives To address in a retrospective and population‐based study prognostic factors for survival time after diagnosis and surgery for glioblastoma multiforme ( GBM ). Material and methods During the study period, 430 patients were identified at the multidisciplinary team conferences as newly diagnosed GBM , 201 of these were considered not to benefit from surgery, and thus, a total of 229 consecutive adult patients with GBM were operated between January 2004 and December 2008 at Sahlgrenska University Hospital and were retrospectively analyzed. Potential predictors of survival were statistically analyzed using Poisson regression models. Results Median survival was 0.73 years. Multivariable analysis showed the following factors to positively influence survival: younger age at surgery, secondary tumor genesis, unifocal tumor location (vs multifocal), resection (vs biopsy only), radiotherapy, and combination of radiotherapy and chemotherapy. Conclusion This population‐based study supports the importance of surgery instead of biopsy only, followed by radiotherapy and chemotherapy, a finding which has also been stated in earlier non‐population‐based reports. However, it is obvious that the solution is not just surgical radicality followed by optimal oncological treatment. It is of great importance to seek further subclassifications, biomarkers, and new treatment modalities to make a significant change in survival for individuals.