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Leptin and metabolic syndrome in patients with Duchenne/Becker muscular dystrophy
Author(s) -
RodríguezCruz M.,
CruzGuzmán O. R.,
Escobar R. E.,
LópezAlarcón M.
Publication year - 2016
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12450
Subject(s) - medicine , hypertriglyceridemia , leptin , duchenne muscular dystrophy , metabolic syndrome , waist , obesity , age groups , endocrinology , body mass index , triglyceride , cholesterol , demography , sociology
Objectives To determine whether patients with Duchenne/Becker muscular dystrophy ( DMD / BMD ) have components of metabolic syndrome (MetSy) and to evaluate whether leptin is associated with components of MetSy. Methods This study included 78 patients (nine, <6 years of age; 54, 6 to <16 years of age; and 15 patients, ≥16 years of age). Obesity and body fat mass were determined by waist circumference and dual‐energy X–ray absorptiometry, respectively. A 12‐h fasting blood sample was collected in the morning. Patients were categorized into four groups according to the number of criteria for MetSy: group 0: none; group 1: one; group 2: two and group 3: three or more criteria. Results All age groups showed components of MetSy. The concentration of these components was significantly higher in patients ≥16 years old. The prevalence of hypertriglyceridemia was from ~37% to 46% in all age groups. The prevalence of MetSy was 7.1% for patients from 6 to <16 years of age and 24% for patients ≥16 years of age. Serum leptin levels increased significantly ( P < 0.05) with age; the highest (13.43 ± 9.4 ng/ml) value was observed in patients >16 years of age. Total leptin was correlated with the number of patients with MetSy ( r = 0.383; P = 0.001). Conclusions Components of MetSy are significant in patients with DMD / BMD . A high prevalence of hypertriglyceridemia was observed. Younger patients with DMD / BMD have risk factors for MetSy. Although leptin increased according to different degrees of MetSy, this relation disappeared when the body fat was corrected by leptin; therefore, the association could be caused by a common risk factor—fat.