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Vitamin D and multiple sclerosis—from epidemiology to prevention
Author(s) -
Sundström P.,
Salzer J.
Publication year - 2015
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12432
Subject(s) - multiple sclerosis , biobank , observational study , epidemiology , vitamin d and neurology , randomized controlled trial , medicine , sun exposure , vitamin , gerontology , psychology , physiology , bioinformatics , biology , immunology , dermatology
In the present review, we discuss observational and experimental data suggesting a protective effect from sun exposure and/or vitamin D in multiple sclerosis ( MS ). These data include geographic variations in MS occurrence, temporal trends, genetics, biobank, and questionnaire data. We look more closely at the differentiation between general effects from UV exposure, and those of vitamin D per se , including plausible mechanisms of action. Finally, primary prevention is touched upon, and we suggest actions to be taken while awaiting the results from ongoing randomized controlled trials with vitamin D in MS .