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The EIF 4G1 gene and Parkinson's disease
Author(s) -
Deng H.,
Wu Y.,
Jankovic J.
Publication year - 2015
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12397
Subject(s) - neurodegeneration , gene , parkinson's disease , biology , gene expression , disease , neuroscience , bioinformatics , genetics , medicine
Variants in the EIF 4G1 gene have been recently identified to be responsible for autosomal dominant PD ( PARK 18 ), but its role in the PD ‐related neurodegeneration is unclear. Several EIF 4G1 mutation/variants were found to be associated with PD , and functional studies have suggested that these variants may impair the ability of cells to rapidly and dynamically respond to stress, thus probably participating in the development of PD , and these indicated that EIF 4G1 variants may play an important role in pathogenicity of PD , although the frequency is low. Further studies involving large sample size of patients with PD from diverse populations, as well as studies of EIF 4G1 expression and in scaffold function, are warranted.