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Vitamin D deficiency in Parkinson's disease patients with orthostatic hypotension
Author(s) -
Jang W.,
Park J.,
Kim J. S.,
Youn J.,
Oh E.,
Kwon K. Y.,
Jo K. D.,
Lee M. K.,
Kim H.T.
Publication year - 2015
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12390
Subject(s) - orthostatic vital signs , calcitriol , supine position , medicine , vitamin d and neurology , parkinson's disease , blood pressure , vitamin d deficiency , endocrinology , gastroenterology , disease
Objectives The purpose of our study was to investigate the associations between serum vitamin D3 levels and orthostatic hypotension ( OH ) in patients with Parkinson's disease ( PD ). Materials and methods Fifty‐five patients with PD were enrolled in this study. Blood pressure ( BP ) measurements were gathered while the patients were in the supine position and while standing up. Then, the patients were divided into two groups: PD patients with and without OH . We compared the levels of serum 25‐hydroxyvitamin D3 and 1, 25‐dihydroxyvitamin D 3 (calcitriol) between the two groups. Results Serum 25‐hydroxyvitamin D and calcitriol levels were significantly decreased in patients with OH compared with those without OH . The systolic and diastolic BPs and symptom severities significantly negatively correlated with the serum 25‐hydroxyvitamin D and calcitriol levels. Conclusions Although the underlying mechanism for this association is not fully understood, our results suggest that low vitamin D status is associated with OH in patients with PD .