Premium
Relationship and factor structure in multisystem neurodegeneration in Parkinson's disease
Author(s) -
Hattori T.,
Orimo S.,
Hallett M.,
Wu T.,
Inaba A.,
Azuma R.,
Mizusawa H.
Publication year - 2014
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12273
Subject(s) - medicine , parkinson's disease , disease , neurodegeneration , risk factor , cardiology , psychology
Objectives Parkinson's disease ( PD ) is a multisystem neurodegenerative disease. We aimed to identify the relationship and factor structure among its different features. Materials & methods Motor, olfactory and cognitive function, and cardiac sympathetic denervation were evaluated in 125 patients with PD using the Unified Parkinson's Disease Rating Scale ( UPDRS ) part III score, odor stick identification test for the Japanese ( OSIT ‐J), Mini‐Mental State Examination ( MMSE ), and [ 123 I] meta‐iodobenzylguanidine ( MIBG ) cardiac scintigraphy (heart‐to‐mediastinum ( H / M ) ratio). Pearson's correlation and multiple regression analysis were used to evaluate the association among the four measures with age, gender, and disease duration as the covariates. Exploratory factor analysis was used to identify the underlying factor structure among the measures and covariates. Results Pearson's correlation and multiple regression analysis showed correlations between OSIT ‐J score and MIBG H / M ratio, OSIT ‐J and MMSE scores, UPDRS part III score and MIBG H/M ratio, UPDRS part III score and disease duration, and MMSE score and age. Factor analysis identified three factors: (i) age and MMSE score; (ii) MIBG H / M ratio and OSIT ‐J score; and (iii) UPDRS part III score and disease duration. Conclusions Our results suggest that aging, PD ‐related pathogenesis, and disease duration underlie the multisystem neurodegeneration present in PD . Moreover, age and disease duration are the major risk factors for cognitive impairment and motor symptoms, respectively. Olfactory impairment and cardiac sympathetic denervation are strongly associated in PD .