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MTHFR C 677 T variant reduces risk of sporadic P arkinson's disease in ethnic C hinese
Author(s) -
Liao Q.,
Li N. N.,
Mao X. Y.,
Chang X. L.,
Zhao D. M.,
Zhang J. H.,
Yu W. J.,
Tan E. K.,
Peng R.
Publication year - 2014
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12245
Subject(s) - methylenetetrahydrofolate reductase , medicine , genotype , gastroenterology , allele , chinese population , single nucleotide polymorphism , disease , genetics , biology , gene
Background Genetic variability of methylenetetrahydrofolate reductase ( MTHFR ) may be associated with P arkinson's disease ( PD ). Its role in ethnic C hinese population is still unclear. Our study aimed to investigate whether MTHFR C 677 T variation was linked to PD risk in a H an C hinese population from mainland C hina. Methods To investigate the association with the risk of PD , we analyzed the single‐nucleotide polymorphism C 677 T in MTHFR gene using a case–control methodology. A total of 1482 subjects included 765 patients with idiopathic PD , and 717 age‐ and sex‐matched controls were recruited in this study. Results The T allele of MTHFR C 677 T was associated with a decreased risk of PD ( OR = 0.80, 95% CI : 0.688–0.926, P = 0.003). Patients with CT + TT genotypes have a decreased risk of PD compared with those with CC genotypes ( OR = 0.66, 95% CI : 0.532–0.813, P = 0.000). CT + TT subjects cannot be differentiated from CC subjects based on their clinical features. Conclusion We showed that the C 677 T polymorphism in MTHFR gene was associated with decreased PD susceptibility in a H an C hinese population from mainland C hina. Efforts to fully elucidate the pathophysiologic role of the variant in PD should be necessary.