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Plasma copeptin and long‐term outcomes in acute ischemic stroke
Author(s) -
Zhang J.L.,
Yin C.H.,
Zhang Y.,
Zhao L.B.,
Fu H.J.,
Feng J.C.
Publication year - 2013
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12132
Subject(s) - copeptin , medicine , hazard ratio , stroke (engine) , receiver operating characteristic , proportional hazards model , prospective cohort study , biomarker , multivariate analysis , cardiology , confidence interval , mechanical engineering , biochemistry , chemistry , engineering , vasopressin
Objective The identification of patients at highest risk for adverse outcome who are presenting with acute ischemic stroke to the emergency department remains a challenge. This study firstly investigates the long‐term prognostic value of the stress marker copeptin in C hinese patients with acute ischemic stroke. Methods In a prospective study, copeptin levels were measured using a new sandwich immunoassay on admission in plasma of 245 consecutive patients with an acute ischemic stroke. The prognostic value of copeptin to predict the functional outcome and mortality within one year was compared with the N ational I nstitutes of H ealth S troke S cale score and with other known outcome predictors. Results Patients with an unfavorable outcomes and non‐survivors had significantly increased copeptin levels on admission ( P < 0.0001 and P < 0.0001). Multivariate C ox regression analysis adjusted for common risk factors showed that copeptin was an independent predictor of functional outcome (hazard ratio = 3.88; 95% CI : 1.94–7.77) and non‐survivors (hazard ratio = 5.99; 95% CI : 2.55–14.07). The area under the receiver operating characteristic curve of copeptin was 0.75 (95% CI , 0.70–0.82) for functional outcome and 0.867 (95% CI , 0.802–0.933) for mortality. Conclusions Copeptin levels are a novel and complementary biomarker to predict functional outcome and mortality 1 year after acute ischemic stroke.