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Resting‐state connectivity of pre‐motor cortex reflects disability in multiple sclerosis
Author(s) -
Dogonowski A.M.,
Siebner H. R.,
Soelberg Sørensen P.,
Paulson O. B.,
Dyrby T. B.,
Blinkenberg M.,
Madsen K. H.
Publication year - 2013
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12121
Subject(s) - multiple sclerosis , resting state fmri , expanded disability status scale , physical medicine and rehabilitation , motor cortex , medicine , neuroscience , functional magnetic resonance imaging , supplementary motor area , psychology , physical therapy , psychiatry , stimulation
Objective To characterize the relationship between motor resting‐state connectivity of the dorsal pre‐motor cortex ( PM d) and clinical disability in patients with multiple sclerosis ( MS ). Materials and methods A total of 27 patients with relapsing–remitting MS ( RR ‐ MS ) and 15 patients with secondary progressive MS ( SP ‐ MS ) underwent functional resting‐state magnetic resonance imaging. Clinical disability was assessed using the E xpanded D isability S tatus S cale ( EDSS ). Independent component analysis was used to characterize motor resting‐state connectivity. Multiple regression analysis was performed in SPM 8 between the individual expression of motor resting‐state connectivity in PM d and EDSS scores including age as covariate. Separate post hoc analyses were performed for patients with RR ‐ MS and SP ‐ MS . Results The EDSS scores ranged from 0 to 7 with a median score of 4.3. Motor resting‐state connectivity of left PM d showed a positive linear relation with clinical disability in patients with MS . This effect was stronger when considering the group of patients with RR ‐ MS alone, whereas patients with SP ‐ MS showed no increase in coupling strength between left PM d and the motor resting‐state network with increasing clinical disability. No significant relation between motor resting‐state connectivity of the right PM d and clinical disability was detected in MS . Conclusions The increase in functional coupling between left PM d and the motor resting‐state network with increasing clinical disability can be interpreted as adaptive reorganization of the motor system to maintain motor function, which appears to be limited to the relapsing–remitting stage of the disease.