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Central nervous system infections and stroke – a population‐based analysis
Author(s) -
Chien L.N.,
Chi N.F.,
Hu C.J.,
Chiou H.Y.
Publication year - 2013
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/ane.12116
Subject(s) - medicine , stroke (engine) , cohort , population , cohort study , myocardial infarction , cerebral infarction , pediatrics , ischemia , mechanical engineering , environmental health , engineering
Background Chronic central nervous system ( CNS ) infections have been found to associate with cerebrovascular complications. Acute CNS infections are more common than chronic CNS infections, but whether they could increase the risk of vascular diseases has not been studied. Methods The study cohort comprised all adult patients with diagnoses of CNS infections from Taiwan National Health Insurance Research Database during 2000–2009 ( n = 533). The comparison group were matched by age, sex, urbanization, diagnostic year, and vascular risk factors of cases (cases and controls = 1:5). Patients were tracked for at least 1 year. Kaplan–Meier analysis was used to compare the risk of stroke and acute myocardial infarction ( AMI ) after adjusting censoring subjects. Results After adjusting the patients demographic characteristics and comorbidities, the risk of patients with CNS infections developing stroke was 2.75–3.44 times greater than their comparison group. More than 70% of the stroke events were occurring within 1 year after CNS infections. The risk of AMI was not found as we compared patients with and without CNS infections. Conclusions The population‐based cohort study suggested that adult patients with CNS infections have higher risk to develop stroke but not AMI , and the risk is marked within a year after infections.