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Triglyceride‐Glucose Index (TyG) is associated with erectile dysfunction: A cross‐sectional study
Author(s) -
Yilmaz Mehmet,
Karaaslan Mustafa,
Tonyali Senol,
Celik Mecit,
Toprak Tuncay,
Odabas Oner
Publication year - 2021
Publication title -
andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 43
eISSN - 2047-2927
pISSN - 2047-2919
DOI - 10.1111/andr.12904
Subject(s) - medicine , erectile dysfunction , triglyceride , diabetes mellitus , endocrinology , metabolic syndrome , cross sectional study , insulin resistance , gastroenterology , outpatient clinic , insulin , cholesterol , pathology
Abstract Background Erectile dysfunction (ED) is often associated with endocrine metabolic diseases such as metabolic syndrome (MetS) and diabetes mellitus (DM), in which insulin resistance (IR) plays a decisive role in pathology. Triglyceride‐glucose index (TyG), a simple, inexpensive and easily accessible IR marker, is calculated by fasting serum glucose and triglyceride values. Objectives We aimed to reveal the relationship between TyG index and ED. Materials and methods Of 152 male patients, aged between 24‐80 years, admitted to the urology outpatient clinic with complaining erectile insufficiency were evaluated. Liver function tests, complete blood count, fasting serum triglyceride, serum testosterone, fasting glucose, fasting insulin, and hemoglobinA1c (HbA1c) were analyzed. TyG index was calculated. All patients were requested to fill in the validated Turkish version of the 5‐item International Index of Erectile Function (IIEF‐5) survey. Results A total of 142 patients were included the study. ED was detected in 91 (64.1%) of the patients. BMI, fasting insulin level, fasting glucose level, IR, GGT, HDL, HbA1c, Triglyceride, TyG, DM, HT, and MetS status of the patients in ED group were statistically significantly higher compared to non‐ED group (all P < .05). It was found that the cutoff value of TyG index for ED was 8.88 (AUC = 0.739, sensitivity 67%, specificity = 68.6%). In multivariate logistic regression analysis, age (OR = 1.07, 95% CI = 1026‐1115, P = .002) and TyG index above 8.88 (OR = 3.865, 95% CI = 1686‐8859, P = .001) were found as independent predictors of ED after accounting for BMI, serum total T and IR. Conclusion TyG index might be useful in the diagnosis and follow‐up of ED.