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The role of inflammatory parameters (neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and monocyte‐to‐eosinophil ratio) in patients with Peyronie's disease
Author(s) -
Özbir S.,
Değirmentepe R. B.,
Atalay H. A.,
Alkan İ.,
Çakır S. S.,
Ötünçtemur A.,
Canat H. L.
Publication year - 2020
Publication title -
andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 43
eISSN - 2047-2927
pISSN - 2047-2919
DOI - 10.1111/andr.12702
Subject(s) - medicine , gastroenterology , univariate analysis , neutrophil to lymphocyte ratio , eosinophil , lymphocyte , diabetes mellitus , peyronie's disease , multivariate analysis , platelet , monocyte , immunology , disease , endocrinology , asthma
Abstract Objectives The aim of the study was to investigate the ability of the systemic inflammatory parameters to predict the discrimination of the phases of Peyronie's disease ( PD ). Materials and methods Demographic, clinical, and laboratory data from 156 patients with PD were analyzed. A complete blood count ( CBC ) was obtained for every patient, and the neutrophil‐to‐lymphocyte ratio ( NLR ), platelet‐to‐lymphocyte ratio ( PLR ), and monocyte‐to‐eosinophil ratio ( MER ) were calculated for every men. Subsequently, patients were divided into two groups based upon the phase of the disease. Results The mean age was 51.9 ± 9.6 in all study population. The mean duration between symptom onset and patient evaluation was 4.2 ± 3.2 months in acute phase group, while it was 32.7 ± 31.7 months in chronic phase group ( p < 0.001). There were no significant differences between the groups according to comorbidities such as diabetes, hypertension, lipid abnormalities, ischemic heart disease, smoking, and alcohol consumption. There was a statistically significant difference in NLR and PLR between two groups ( p = 0.008, p = 0.008, respectively). NLR and PLR were significantly correlated with discrimination status in univariate analysis ( p = 0.003, p = 0.005, respectively). Multivariate regression analysis revealed that NLR was the only independent risk factor for discrimination of the phases of PD ( p < 0.001). The ROC analysis revealed a cutoff value of 1.8 ( AUC 0.712, p < 0.001; sensitivity 61.1%; specificity 75.0%) for the NLR . Conclusion Our study demonstrated that NLR could be helpful to differentiate the chronic phase from the acute phase in patients with PD . Therefore, NLR could be used as an objective biomarker to the management of the disease and choosing the appropriate treatment.