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IGF signalling in germ cells and testicular germ cell tumours: roles and therapeutic approaches
Author(s) -
Selfe J.,
Shipley J. M.
Publication year - 2019
Publication title -
andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 43
eISSN - 2047-2927
pISSN - 2047-2919
DOI - 10.1111/andr.12658
Subject(s) - germ cell , cancer research , growth factor , biology , phenotype , cancer , cell growth , function (biology) , bioinformatics , immunology , microbiology and biotechnology , receptor , genetics , gene
The insulin‐like growth factor ( IGF ) axis plays key roles in normal tissue growth and development as well as in the progression of several tumour types and their subsequent growth and progression to a metastatic phenotype. This review explores the role of IGF system in normal germ cell development and function in addition to examining the evidence for deregulation of IGF signalling in cancer, with particular relevance to evidence supporting a role in testicular germ cell tumours ( TGCT s). Despite the clear preclinical rationale for targeting the IGF axis in cancer, there has been a lack of progress in identifying which patients may benefit from such therapy. Future employment of agents targeting the IGF pathway is expected to concentrate on their use in combination with other treatments to prevent resistance and exploit their potential as chemo‐ and radiosensitizers.