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Primary cilia: biosensors of the male reproductive tract
Author(s) -
Girardet Laura,
Augière Céline,
Asselin MariePier,
Belleannée Clémence
Publication year - 2019
Publication title -
andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 43
eISSN - 2047-2927
pISSN - 2047-2919
DOI - 10.1111/andr.12650
Subject(s) - cilium , context (archaeology) , biology , organelle , infertility , female reproductive tract , microbiology and biotechnology , neuroscience , sperm , genetics , pregnancy , paleontology
Background The primary cilium is a microtubule‐based organelle that extends transiently from the apical cell surface to act as a sensory antenna. Initially viewed as a cellular appendage of obscure significance, the primary cilium is now acknowledged as a key coordinator of signaling pathways during development and in tissue homeostasis. Objectives The aim of this review was to present the structure and function of this overlooked organelle,with an emphasis on its epididymal context and contribution to male infertility issues. Materials and Methods A systematic review has been performed in order to include main references relevant to the aforementioned topic. Results Increasing evidence demonstrates that primary cilia dysfunctions are associated with impaired male reproductive system development and male infertility issues. Discussion While a large amount of data exists regarding the role of primary cilia in most organs and tissues, few studies investigated the contribution of these organelles to male reproductive tract development and homeostasis. Conclusion Functional studies of primary cilia constitute an emergent and exciting new area in reproductive biology research.