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Sperm morphological normality under high magnification is correlated to male infertility and predicts embryo development
Author(s) -
Zanetti B. F.,
Braga D. P. A. F.,
Provenza R. R.,
Figueira R. C. S.,
Iaconelli A.,
Borges E.
Publication year - 2018
Publication title -
andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 43
eISSN - 2047-2927
pISSN - 2047-2919
DOI - 10.1111/andr.12473
Subject(s) - intracytoplasmic sperm injection , male infertility , infertility , semen analysis , andrology , blastocyst , sperm , human fertilization , gynecology , pronucleus , assisted reproductive technology , semen , in vitro fertilisation , biology , medicine , embryo , pregnancy , embryogenesis , zygote , anatomy , genetics
Summary Human sperm morphology has been described as an essential parameter for the diagnosis of male infertility and a prognostic indicator of natural or assisted pregnancies. Nevertheless, standard morphological assessment remains a subjective analysis and its impact on intracytoplasmic sperm injection ( ICSI ) is also of limited value. The objective of this prospective cohort study was to investigate whether motile sperm organelle morphology examination ( MSOME ) can improve semen analysis by better defining male infertility and providing a better prognosis for ICSI up to a year later. Data were obtained from 483 patients undergoing conventional semen analysis from June 2015 to June 2017 in a private university‐affiliated in vitro fertilization ( IVF ) center. The correlation of MSOME with seminal parameters was evaluated. One hundred and thirty patients underwent ICSI up to a year later, and the correlation between MSOME and ICSI outcomes was established. Except for volume, all seminal parameters were positively correlated with MSOME I+ II . MSOME was also distinct between World Health Organization ( WHO ) classification groups, with normozoospermic and oligoasthenoteratozoospermic presenting the higher and the lower proportion of MSOME I+ II , respectively. MSOME I+ II was prognostic for fertilization rate, high‐quality cleavage‐stage embryos rate, and blastocyst rate. The normality cutoff value based on blastocyst rate was MSOME I+ II ≥ 5.5%. MSOME could be a useful tool for the diagnosis of infertility severity as it is correlated with sperm morphology, motility, and concentration. Men who had higher MSOME I+ II had better ICSI outcomes. The future use of MSOME as a routine method for semen analysis may be a reliable form of assessing male infertility.