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Effect of B9 and B12 vitamin intake on semen parameters and fertility of men with MTHFR polymorphisms
Author(s) -
Najafipour R.,
Moghbelinejad S.,
Aleyasin A.,
Jalilvand A.
Publication year - 2017
Publication title -
andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 43
eISSN - 2047-2927
pISSN - 2047-2919
DOI - 10.1111/andr.12351
Subject(s) - methylenetetrahydrofolate reductase , oligospermia , male infertility , vitamin b12 , genotype , azoospermia , semen , sperm , semen quality , medicine , homocysteine , spermatogenesis , semen analysis , endocrinology , gene polymorphism , biology , infertility , andrology , genetics , pregnancy , gene
Summary The methylenetetrahydrofolate reductase ( MTHFR ) gene codes a crucial enzyme which involve in folate metabolism. The effect of MTHFR gene polymorphisms on male fertility status is uncertain and controversial. We evaluated the effect of B vitamin family intake on total homocysteine content and semen parameters of men with MTHFR gene polymorphisms. MTHFR genotypes frequency and serum total homocysteine concentration were measured among 280 men with impaired spermatogenesis (asthenospermia, oligospermia, severe oligospermia and azoospermia) and 85 control participants. B vitamin family dietary intakes were assessed using a semi‐quantitative food‐frequency questionnaire. In addition, concentrations of vitamins B9 and B12 were evaluated in serum samples of some participants ( n = 60). We observed significantly higher frequency of TC or TT genotypes in C677T polymorphism among oligospermic, severe oligospermic and azoospermic men. CC genotype of A1298C polymorphism was significantly higher only in azoospermic men. Also, we observed critical effect of vitamin B9 and B12 intake on decreasing of total homocysteine and improving of semen parameters among the men with T allele of MTHFR C677T polymorphism. Our investigation showed that sufficient consumption of vitamins B9 and B12 influences sperm parameters of men with different MTHFR polymorphisms, especially genotypes with T allele.