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Testosterone level and endothelial dysfunction in patients with vasculogenic erectile dysfunction
Author(s) -
Omar Y. A.,
Younis S. E.,
Ismail I. Y.,
ElSakka A. I.
Publication year - 2017
Publication title -
andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 43
eISSN - 2047-2927
pISSN - 2047-2919
DOI - 10.1111/andr.12347
Subject(s) - erectile dysfunction , endothelial dysfunction , medicine , testosterone (patch) , urology , gastroenterology , endocrinology , gynecology
Summary The association between endothelial dysfunction and late onset hypogonadism ( LOH ) in patients with vasculogenic erectile dysfunction ( ED ) is not yet well settled. Our objective was to assess the association between LOH and endothelial dysfunction in patients with vasculogenic ED . Throughout 2014–2015 a total of 90 men were enrolled in this cross‐sectional observational study. Of them 60 patients with a clinical diagnosis of ED were further subdivided into two equal groups: patients with vasculogenic ED and LOH (A); patients with vasculogenic ED and euogonadal (B). Thirty age‐matched men with no ED or hypogonadism were enrolled as control group (C). All patients were subjected to detailed medical and sexual history, total testosterone ( TT ), calculated free ( FT ) and bioavailable testosterone ( BT ), flow cytometric evaluation for endothelial progenitor cells ( EPC s) ( CD 45negative/ CD 34positive/ CD 144positive) and endothelial microparticles ( EMP s) ( CD 45negative/ CD 144positive/annexin V positive). The mean age ± SD of the three groups A, B and C were 51.3 ± 11.1, 53.6 ± 10.6 and 48.3 ± 5 years, respectively, with insignificant age differences ( p = 0.089). The diagnostic criteria of LOH were adapted according to European male aging study, 2010. The means of TT (ng/mL) were 2.32 ± 0.21, 6.43 ± 0.36 and 5.37 ± 0.30 in groups A, B and C, respectively. There were highly significant differences between group A and groups B and C ( p < 0.001 for each). The means of EPC s were 0.43 ± 0.070, 0.22 ± 0.05 and 0.032 ± 0.013 in groups A, B and C, respectively. The means of EMP s were 0.15 ± 0.029, 0.056 ± .013 and 0.014 ± 0.002 in groups A, B and C, respectively. There were significant differences between group C and groups A and B ( p < 0.05 for each). This study clearly demonstrated that there is a significant association between LOH and the higher expression of EPC s and EMP s in patients with vasculogenic ED .