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Intracytoplasmic morphologically selected sperm injection and congenital birth defects: a retrospective cohort study
Author(s) -
HershkoKlement A.,
SukenikHalevy R.,
Biron Shental T.,
Miller N.,
Berkovitz A.
Publication year - 2016
Publication title -
andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 43
eISSN - 2047-2927
pISSN - 2047-2919
DOI - 10.1111/andr.12221
Subject(s) - medicine , intracytoplasmic sperm injection , obstetrics , retrospective cohort study , pregnancy , cohort , singleton , gynecology , cohort study , infertility , biology , surgery , pathology , genetics
Summary Our objective was to study the birth defect rates in intracytoplasmic morphologically selected sperm injection ( IMSI ) pregnancies. A cohort of couples presenting male factor infertility between January 2006 and January 2014 was retrospectively analyzed. Discharge letters and a telephone interview were performed for assessing pregnancy outcome. All clinical data were reviewed by a board certified medical geneticist. Main outcomes were fetal/birth defect and chromosomal abnormality rates. Two thousand two hundred and fifty‐eight pregnancies were available for analysis, of them, 1669 (73.9%) resulting from ICSI and 2258 (26.1%) achieved by IMSI . Pregnancy outcome distribution did not show a significant difference. For the fresh embryo transfer cohort, fetal/birth defect rate was 4.5%, chromosomal aberration rate was 1.0%, and structural malformation rate was 3.5%. IMSI vs. ICSI pregnancies were less likely to involve a fetal/birth defect: 3.5% vs. 4.8%, respectively, but did not reach a statistical significance OR 0.71 (95% CI 0.39–1.22). Split by multiplicity, this trend existed only for singleton pregnancies; 1.4% structural malformations rate vs. 3.8%, respectively, OR 0.35 (95% CI 0.11–0.9). The frozen cohort demonstrated a significantly lower birth defect rate ( OR 0.25, 95% CI 0.09–0.58). We conclude that IMSI procedure does not involve an increased malformation rate and may offer a reduced anomaly incidence. Further studies are required.