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Use of selective serotonin reuptake inhibitors reduces fertility in men
Author(s) -
Nørr L.,
Bennedsen B.,
Fedder J.,
Larsen E. R.
Publication year - 2016
Publication title -
andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 43
eISSN - 2047-2927
pISSN - 2047-2919
DOI - 10.1111/andr.12184
Subject(s) - serotonin , serotonin uptake inhibitors , fertility , serotonin reuptake inhibitor , pharmacology , psychiatry , medicine , fluoxetine , environmental health , population , receptor
Summary Clinical review of the present data on the effects of selective serotonin reuptake inhibitors ( SSRI s) on male fertility was the objective of the study. PubMed and Scopus were searched for publications in English or Danish and reviewed. Human trials, animal studies and in vitro studies were included. Use of SSRI s negatively affects semen parameters in most studies. In some studies, SSRI s are also shown to reduce DNA integrity. SSRI s can also delay ejaculation. Depression and anxiety can cause reduced libido, erectile dysfunction and delayed ejaculation as well. The use of SSRI s seems to reduce male fertility by affecting semen parameters, although most studies have a degree of confounding by indication caused by the underlying depression.