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Combination of vitamin E and clomiphene citrate in treating patients with idiopathic oligoasthenozoospermia: A prospective, randomized trial
Author(s) -
ElSheikh M. G.,
Hosny M. B.,
Elshenoufy A.,
Elghamrawi H.,
Fayad A.,
Abdelrahman S.
Publication year - 2015
Publication title -
andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 43
eISSN - 2047-2927
pISSN - 2047-2919
DOI - 10.1111/andr.12086
Subject(s) - medicine , male infertility , infertility , vitamin e , randomized controlled trial , sperm , urology , semen analysis , semen quality , semen , prospective cohort study , sperm motility , gynecology , gastroenterology , andrology , antioxidant , pregnancy , biochemistry , genetics , biology , chemistry
Summary The most common cause of male infertility is idiopathic oligoasthenozoospermia. Empirical medical treatment for idiopathic male infertility is still a controversial issue. The aim of this study was to evaluate any possible effects of combining vitamin E as antioxidant and clomiphene citrate as antiestrogen on spermatozoa concentration and motility in comparison to give either of medications alone in patients with idiopathic oligoasthenozoospermia. This is a comparative prospective randomized study. Ninety patients with idiopathic oligoasthenozoospermia were randomized into equally three groups: Group A: received vitamin E (400 mg/day) for 6 months. Group B: received clomiphene citrate (25 mg daily) for 6 months. Group C: received combination of both drugs in the same doses for 6 months. All patients were subjected to the following: history taking, general and genital examination, semen analysis, serum FSH , total testosterone, and scrotal duplex. Semen examination was performed according to the guidelines of (WHO, 2010), at the start of treatment and was repeated after 3 months and after 6 months of treatment. Regarding vitamin E group, there was insignificant increase in mean sperm concentration after 6 months of treatment in comparison to baseline. On the other hand, there was a significant improvement of mean sperm concentration in the other two groups after 6 months of treatment, with more significance in combination therapy group ( p = 0.001). The mean total sperm motility has improved in all patients groups, in comparison to baseline, with more significance in combination therapy group. In vitamin E group, it was 28.07 ± 9.65% ( p = 0.000). For those in clomiphene citrate group, was 33.33 ± 14.10% ( p = 0.003) and 40.50 ± 17.54% ( p = 0.000) in combination therapy group. Combining antioxidant and anti‐estrogen therapy is a valid option for the treatment of a selected group of men with unexplained isolated oligoasthenozoospermia.