Premium
Association between etiologic factors in infertile couples and fertilization failure in conventional in vitro fertilization cycles
Author(s) -
Zhu J.,
Jiang H.,
He R.B.,
Yin H.Q.,
Wang C.L.,
Li Y.,
Du X.
Publication year - 2015
Publication title -
andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 43
eISSN - 2047-2927
pISSN - 2047-2919
DOI - 10.1111/andr.12048
Subject(s) - intracytoplasmic sperm injection , infertility , medicine , in vitro fertilisation , male infertility , gynecology , group b , andrology , human fertilization , assisted reproductive technology , etiology , obstetrics , pregnancy , biology , genetics , anatomy
Summary The aim of this study was to investigate the relationship between the etiology of the couples and risk of fertilization failure ( FF ) in conventional in vitro fertilization ( IVF ) cycles and the effect of rescue intracytoplasmic sperm injection ( ICSI ) technique to offspring. A total of 2542 IVF cycles were divided into four groups according to infertile etiology: Group A – primary infertility with normal semen parameters; Group B – secondary infertility with oligoasthenozoospermia; Group C – primary infertility with oligoasthenozoospermia; and Group D – secondary infertility with normal semen parameters. The results showed that there were significant differences in incidence of FF among Group A (16.8%), Group B (20.9%), Group C (48.7%), and Group D (0.9%) ( p < 0.001). Logistic regression models demonstrated that primary infertility ( OR : 10.898, 95% CI : 4.651–25.583, p < 0.001) and oligoasthenozoospermia ( OR : 12.215, 95% CI : 5.903–25.276, p < 0.001) were independent risk factors for FF . There were no significant differences in main outcomes between conventional ICSI and rescue ICSI . In conclusion, the patients with primary infertility and oligoasthenozoospermia might be at higher risk of FF . The rescue ICSI technique is safe and helpful for IVF cycles of FF .