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Protective effects of crocin on acrylamide‐induced testis damage
Author(s) -
Gül Mehmet,
Kayhan Kuştepe Elif,
Erdemli Mehmet Erman,
Altınöz Eyüp,
Gözükara Bağ Harika Gözde,
Gül Semir,
Göktürk Nurcan
Publication year - 2021
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.14176
Subject(s) - crocin , malondialdehyde , superoxide dismutase , oxidative stress , antioxidant , endocrinology , glutathione , medicine , histopathology , testosterone (patch) , chemistry , lipid peroxidation , acrylamide , seminiferous tubule , reproductive toxicity , spermatogenesis , andrology , toxicity , sertoli cell , biochemistry , pathology , enzyme , organic chemistry , copolymer , polymer
Exposure to acrylamide (Ac) through food is almost inevitable and this kind of toxicity may cause lifelong harm. In present study, we researched effects of Crocin (Cr) on testis histopathology in Ac‐induced testis of rats. Adult male rats were grouped as: group 1, 1 ml saline only; group 2, 50 mg/kg Cr only; group 3, 25 mg/kg Ac only and group 4, 25 mg/kg Ac + 50 mg/kg Cr. All administrations were given as 1 ml/day by gavage for 21 days. It was found that Ac adversely influenced the levels of FSH, testosterone and LH in the blood serum; malondialdehyde (MDA), total antioxidant status (TOS), oxidative stress index (OSI)/ glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), total antioxidant status (TAS) oxidant/antioxidant parameters in testis tissue ( p < .01) and the histopathological parameters like Johnson's score, seminiferous tubule diameter, seminiferous epithelial height and H‐score for caspase‐3 immunoreactivity. In contrary, Cr treatment resulted in increase in testosterone, follicle stimulating hormone (FSH), luteinizan hormone (LH) levels and SOD, CAT, GSH, TAS levels ( p < .01) and improved all the histopathological changes. In conclusion, Cr has a promising protective potential against Ac‐caused toxic damages in testicular tissue.