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Expression of brain‐derived neurotrophic factor in rapid ejaculator rats: A further study
Author(s) -
Huang Yuanyuan,
Peng Dangwei,
Geng Hao,
Dai Yutian,
Jiang Hui,
Zhang Xiansheng
Publication year - 2021
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.14134
Subject(s) - ejaculation , brain derived neurotrophic factor , central nervous system , neurotrophic factors , spinal cord , medicine , endocrinology , premature ejaculation , neuroscience , biology , psychology , receptor , psychoanalysis
Limited evidence has indicated that brain‐derived neurotrophic factor (BDNF) may be involved in the neurobiology of premature ejaculation (PE). This study aimed to investigate BDNF levels in the central and peripheral nervous systems of a rapid ejaculation model. Eighteen male rats were selected and classified as ‘sluggish’, ‘normal’ and ‘rapid’ ejaculators on the basis of ejaculation frequency during copulatory behavioural tests. BDNF levels in specific brain regions, spinal cord and serum were determined by enzyme‐linked immunosorbent assay (ELISA). Consistent with the results in PE patients, the concentration of serum BDNF decreased significantly from the sluggish rats to normal and rapid rats. Besides, in both brain regions and spinal cord, the sluggish group had the highest BDNF levels, while the rapid group had the lowest BDNF levels. Regression analyses of the expression of BDNF presented positive correlations between serum and brain ( r = 0.958, p < .001), and between serum and spinal cord ( r = 0.967, p < .001) respectively. Our findings suggested insufficient BDNF in the nervous system and serum may lead to rapid ejaculation. The current study adds to the evidence that BDNF is involved in the regulation of ejaculation.