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Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats
Author(s) -
Famurewa Ademola C.,
EkelemeEgedigwe Chima A.,
Onwe Chikodili S.,
Egedigwe Uchenna O.,
Okoro Chukwuemeka O.,
Egedigwe Ugochukwu J.,
Asogwa Nnaemeka T.
Publication year - 2020
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13786
Subject(s) - oxidative stress , malondialdehyde , glutathione , antioxidant , nitric oxide synthase , pharmacology , nitric oxide , cisplatin , proinflammatory cytokine , toxicity , chemistry , inflammation , endocrinology , medicine , biochemistry , enzyme , chemotherapy
The off‐target testicular toxicity of the anticancer drug, cisplatin, is a current clinical concern and worrisome to male cancer patients. Growing evidence has implicated oxidative stress and inflammation in cisplatin toxicity. We have explored whether fresh ginger juice could mitigate testicular toxicity induced by anticancer drug cisplatin in rats. Rats were subjected to oral administration of fresh ginger juice (5 ml/kg body weight/day) for 5 days against testicular damage induced by single ip injection of cisplatin (CIS) (10 mg/kg body weight) on day 2 only. Testicular activities of antioxidant enzymes, malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), inflammatory cytokines, inducible nitric oxide synthase (iNOS) and nuclear factor‐ĸB (NF‐ĸB) and serum hormone levels were estimated. CIS‐induced prominent decreases in antioxidant enzyme activities, GSH and serum hormone levels, whereas levels of MDA, cytokines, NO, iNOS and NF‐ĸB increased remarkably ( p < .05) compared to control. Interestingly, the CIS‐induced testicular alterations were considerably mitigated by the fresh ginger juice via abrogation of oxidative stress and anti‐inflammatory mechanism. The study suggests, for the first time, antioxidant and anti‐inflammatory effects of ginger juice against CIS testicular damage. Fresh ginger juice may have beneficial health impact on testicular side effect of CIS chemotherapy.