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Insulin resistance and idiopathic infertility: A potential possible link
Author(s) -
Saleh Ahmed Abd El Wahab,
Amin Eman Mahmoud,
Elfallah Asmaa Adel,
Hamed Ahmed Mohamed
Publication year - 2020
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13773
Subject(s) - infertility , insulin resistance , medicine , adipokine , obesity , male infertility , physiology , metabolic syndrome , diabetes mellitus , female infertility , endocrinology , gynecology , pregnancy , biology , genetics
Among various health issues, infertility has been always considered as one of the major health problems. Idiopathic infertility is still a matter of debate since the underlying mechanisms stay obscure. Idiopathic infertility is related to expanded chance of metabolic syndrome components, obesity and increased risk of cardiovascular diseases. This study aimed to assess insulin resistance and serum levels of irisin as one of the adipokines in patients with idiopathic infertility. This study included 50 male patients aged 25–50 years old suffering from idiopathic infertility, together with 50 healthy individuals of matched age as controls. Patients showed significantly increased homeostasis model assessment for insulin resistance values than controls. For irisin results, idiopathic infertility patients had significantly decreased values than controls indicating the potential effect of irisin in development of insulin resistance in idiopathic infertility patients.