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Does in vitro application of pentoxifylline have beneficial effects in assisted male reproduction?
Author(s) -
Mahaldashtian Maryam,
Khalili Mohammad Ali,
Nottola Stefania Annarita,
Woodward Bryan,
Macchiarelli Guido,
Miglietta Selenia
Publication year - 2021
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13722
Subject(s) - pentoxifylline , reproduction , in vitro , male fertility , in vitro fertilisation , medicine , andrology , biology , pharmacology , chemistry , microbiology and biotechnology , fertility , biochemistry , genetics , embryo , population , environmental health
Application of nonspecific phosphodiesterases inhibitors, such as pentoxifylline (PTX), is a strategy utilised to aid sperm selection from immotile sperm samples prior to ICSI. No extensive studies have yet been performed to verify the safety of the clinical outcomes of ICSI after PTX administration. In this article, we summarise the data reported in the literature that assess the implication of in vitro usage of PTX on sperm parameters, as well as clinical outcomes during assisted male reproduction programme.