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Protective effects of Ranolazine on testicular torsion and detorsion injury in rats
Author(s) -
Keseroglu Bilge Bugra,
Ozer Elif,
Karakan Tolga,
Ozgur Berat Cem,
Surer Hatice,
Ogus Elmas,
Hucemenoglu Sema,
Yuceturk Cem Nedim,
Agras Koray
Publication year - 2020
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13616
Subject(s) - ranolazine , medicine , testicular torsion , pharmacology , spermatic cord torsion , pathological , torsion (gastropod) , urology , anesthesia , surgery
Ranolazine is a drug used in refractory chronic stable angina. In this study, it was aimed to evaluate the protective effect of ranolazine in a testis torsion model in light of objective biochemical and pathological data. A total of 24 pre‐pubertal male Wistar albino rats were separated into three groups of 8 as the sham group, control group and ranolazine group. Testis torsion was applied for 3 hr to all the rats in Group Control and Group Ranolazine. In Group Control, 0.9% NaCl was applied 1 hr after the torsion. In Group Ranolazine, ranolazine 30 mg/kg was dissolved in a 0.9% NaCl solution and was administered intraperitoneally 1 hr after torsion. Histopathological evaluation was made using the Cosentino score. As a result of the objective biochemical and pathological criteria used in this study, this protective effect of ranolazine was observed in testis torsion. The results obtained in this study may suggest that ranolazine is a drug that could be applied after detorsion to patients diagnosed with torsion.