Premium
Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats
Author(s) -
Kandemir Fatih Mehmet,
Caglayan Cuneyt,
Aksu Emrah Hicazi,
Yildirim Serkan,
Kucukler Sefa,
Gur Cihan,
Eser Gizem
Publication year - 2020
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13524
Subject(s) - rutin , malondialdehyde , chemistry , saline , toxicity , necrosis , antioxidant , sperm motility , oxidative stress , catalase , andrology , sperm , pharmacology , endocrinology , medicine , biochemistry
This study investigated the effects of rutin against reproductive damage caused by toxic mercury in male rats. Thirty‐five Sprague Dawley rats were used. Control group was injected with saline for 7 days. The rutin‐100 group received 100 mg/kg/b.w. rutin for 7 days. Mercuric chloride (HgCl 2 ) group received 1.23 mg/kg/b.w. of HgCl 2 for 7 days. Mercury chloride + rutin‐50 group received 50 mg/kg/b.w. rutin and HgCl 2 1.23 mg/kg/b.w. for 7 days. HgCl 2 + rutin‐100 group received 100 mg/kg/b.w. rutin and HgCl 2 1.23 mg/kg/b.w. for 7 days. It was detected that HgCl 2 treatment increased malondialdehyde (MDA) levels, tumour necrosis factor‐α (TNF‐α) and cyclooxygenase‐2 (COX‐2) expressions, necrosis and degeneration of spermatogonium, dead and abnormal sperm percentages; tubular walls thinning; and decreased antioxidant enzyme activities and sperm motility. It was determined that rutin application reduced testicular damage caused by HgCl 2 . In conclusion, rutin administration may treat HgCl 2 toxicity in testes.