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The influence of l ‐carnitine on the expression of miRNAs in asthenospermia spermatozoa and the network regulation of the associated molecules
Author(s) -
Liu Lin,
Li Tao,
Li Famingzi,
Zhao Xiaodong,
Zhang Rui,
Liu Jing,
Zhang Wei,
Lu Jianqi,
Zhang Xuehong,
Ma Xiaoling
Publication year - 2020
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13478
Subject(s) - microrna , kegg , motility , microbiology and biotechnology , carnitine , biology , sperm , sperm motility , regulation of gene expression , gene expression , function (biology) , male infertility , hedgehog signaling pathway , gene , signal transduction , infertility , transcriptome , genetics , biochemistry , pregnancy
l ‐carnitine is a natural compound that is indispensable for energy metabolism in mammals. The efficiency and safety of l ‐carnitine in improving sperm activity, enhancing epididymal function and treating male infertility has been widely acknowledged by clinicians. CircRNAs can regulate gene expression at the transcriptional or post‐transcriptional level by serving as a molecular sponge of miRNAs with miRNA response elements. However, the detailed mechanism linking miRNA, circRNA and asthenospermia remains unclear. The present study demonstrated that hsa‐miR‐27b‐3p, hsa‐miR‐151a‐5p and hsa‐miR‐206 play an important role in the effects of l ‐carnitine treatment of the spermatozoa in asthenospermia patients. Furthermore, the target mRNAs of hsa‐miR‐206 were analysed by GO and KEGG. The results show that the target mRNAs of hsa‐miR‐206 may change the activity of ATP synthase and participate in the cAMP signalling pathway and the calcium signalling pathway, which may play an important role in sperm motility.