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Cuscuta chinensis flavonoids alleviate bisphenol A‐induced apoptosis of testicular cells in male mice offspring
Author(s) -
Wei Yuanyuan,
Li Shuying,
Han Chao,
Bao Yongzhan,
Shi Wanyu
Publication year - 2019
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13427
Subject(s) - offspring , apoptosis , biology , andrology , endocrine disruptor , gestation , medicine , endocrinology , bisphenol a , endocrine system , pregnancy , hormone , chemistry , genetics , organic chemistry , epoxy
Bisphenol A (BPA) is a widespread environmental endocrine disruptor that has multiple effects on reproductive organ development. To investigate the effect of Cuscuta chinensis flavonoids (CCFs) on testicular apoptosis induced by BPA in male mice offspring, pregnant mice were administered intragastrically with BPA and CCF at gestation day (GD) 0.5–17.5. The testes of male offspring (F1 males) were collected at post‐natal day (PND) 21 and PND 56 for the detection of related indicators. The results showed that compared with the BPA group, the testicular index in CCF groups was significantly increased at PND 21 ( p < .01). For the mice of different concentrations of CCF groups, the expression levels of bax, caspase‐9 and caspase‐7 proteins were significantly decreased at PND 21 and PND 56, while the expression level of bcl‐2 protein was significantly increased, and testicular apoptotic cells were also decreased significantly ( p < .01 or p < .05). Forty mg/kg CCF has no significant difference compared with the control group. The results indicated that CCF could protect the testis development of F1 male mice by alleviating the apoptosis of testicular cells induced by BPA.