Premium
Sperm parameters quality and reproductive effects of methanolic extract of Alchornea cordifolia leaves on senescent male rats
Author(s) -
Ngaha Njila Marie Ide,
Massoma Lembè Dieudonné,
Koloko Brice Landry,
Yong Meng Goh,
Ebrahimi Mahdi,
Awad Elmutaz Atta,
Hasan Baiee Falah,
Kenmogne Hubert,
Hambe Magloire,
Mandenguè Samuel Honoré
Publication year - 2019
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13359
Subject(s) - epididymis , sperm , testosterone (patch) , biology , spermatogenesis , distilled water , endocrinology , medicine , chemistry , botany , chromatography
The effect of the methanolic extract of Alchornea cordifolia leaves on the fertility of senescent male rats was assessed in this study. 40 rats received daily distilled water, testosterone, 200 and 400 mg/kg of extract of Alchornea cordifolia . The reproductive organs weight, the gonadotropins, testosterone and cholesterol level, the sperm parameters, histology of the testes and epididymis were assessed. The weight of testes and prostate (400 mg/kg) significantly increased ( p < 0.05) as well as the level of FHS ( p < 0.001), LH and testosterone ( p < 0.01) at a dose of 400 mg/kg, respectively, while the cholesterol decreased at a dose of 200 mg/kg ( p < 0.05) and 400 mg/kg ( p < 0.01) respectively. The testes and epididymis were full of spermatozoa particularly at a dose of 400 mg/kg. The sperm count and morphology significantly increased at both doses of 200 mg/kg ( p < 0.01; p < 0.001) and 400 mg/kg ( p < 0.001; p < 0.01) respectively. The sperm motion (PROG, VAP, VSL, VCL) ( p < 0.001), (ALH, BCF) ( p < 0.05) increased at a dose of 200 mg/kg and decreased at a dose of 400 mg/ kg. The overall results provide the strong evidence of the fertility potential of the methanolic extract of Alchornea cordifolia leaves in senescent male rats.