Premium
Effect of p ‐coumaric acid on the erectogenic enzyme activities and non‐protein thiol level in the penile tissue of normal and doxorubicin‐induced oxidative stress male rat
Author(s) -
Oyeleye Sunday Idowu,
Adefegha Stephen Adeniyi,
Dada Felix Abayomi,
Okeke Bathlomew Maduka,
Oboh Ganiyu
Publication year - 2019
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13281
Subject(s) - oxidative stress , endocrinology , medicine , chemistry , thiol , doxorubicin , enzyme assay , pharmacology , antioxidant , enzyme , biochemistry , chemotherapy
This study investigated effect of p ‐coumaric acid (PCA) on erectogenic enzyme activity and non‐protein thiol level in the penile tissue of normal and doxorubicin (DOX)‐induced oxidative stress male rat. Sixty‐four (64) adult male rats weighing between 170 and 180 g were used for this work. After 14 days of acclimatisation, the rats were divided into eight groups ( n = 8). Rats were orally pre‐treated with PCA dose dependently (50 and 100 mg/kg body weight [b.w.t]) and vitamin E (100 mg/kg b.w.t) for 14 days before induction with a single dose of DOX (15 mg/kg b.w.t, via i.p.). The result revealed that arginase, acetylcholinesterase (AChE), angiotensin‐I‐converting enzyme (ACE), phosphodiesterase‐5 (PDE‐5), adenosine monophosphohydrolase (AMPdase) activities were significantly ( p < 0.05) higher in the DOX‐induced rats as against the control, which was significantly p < 0.05) higher when compared to normal rats treated with PCA. PCA also improved non‐protein thiol level in the penile tissue of both normal and DOX‐induced rats. Hence, this study revealed that PCA is capable of causing inhibitory effects on the activities of enzymes, associated with oxidative stress‐induced erectile dysfunction (ED) and could also be used as an aphrodisiac agent in the management/treatment of ED.