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Sperm protein carbonylation
Author(s) -
Lone Shabir Ahmad,
Mohanty Tushar Kumar,
Baithalu Rubina Kumari,
Yadav Hanuman Prasad
Publication year - 2019
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13233
Subject(s) - sperm , capacitation , protein carbonylation , cryopreservation , oxidative stress , chemistry , reactive oxygen species , biology , andrology , microbiology and biotechnology , biochemistry , lipid peroxidation , genetics , embryo , medicine
The cryopreservation of sperm is a well established technique that plays an essential role in dissemination of elite germplasm of livestock. Despite having numerous advantages, the cryopreservation induces certain stresses on sperm including structural and functional damages leading to impaired sperm quality and fertility, which might be associated with production of reactive oxygen species (ROS). In addition, the ROS upon reacting with sperm lipids, DNA and proteins may lead to a cascade of sperm damages. The sperm membrane contains a rich amount of polyunsaturated fatty acids, which increases their susceptibility to oxidative stress induced damages, leading to formation of secondary products. These secondary products result in oxidation of sperm proteins via carbonylation. The carbonylation could lead to disturbances in specific proteins that are involved in capacitation. The present review deals with sperm protein carbonylation.