Premium
TP53 gene Arg72Pro polymorphism and male infertility risk: A meta‐analysis
Author(s) -
Ren ZhengJu,
Zhang Qin,
Ren PengWei,
Yang Bo,
Liu ShengZhuo,
Liao Jian,
Yang LuCheng,
Lu DongLiang,
Liu LiangRen,
Dong Qiang
Publication year - 2018
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13122
Subject(s) - odds ratio , confidence interval , male infertility , infertility , meta analysis , medicine , subgroup analysis , population , chinese population , gynecology , polymorphism (computer science) , gastroenterology , genetics , genotype , biology , gene , pregnancy , environmental health
To evaluate the association between TP53 codon72 polymorphism and male infertility risk. We conducted a search on Medline, Embase, Web of Science and CNKI up to April 30, 2017. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the strength of the association. Seven studies including 1,818 cases and 2,278 controls met the inclusion criteria. The pooled results indicated that no significant association was observed between TP53 codon72 polymorphism and male infertility risk (G versus C: OR = 1.11, 95%CI = 0.94–1.32; GG versus CC: OR = 1.26, 95%CI = 0.90–1.78; GG versus GC+CC: OR = 1.16, 95%CI = 0.90–1.49; GG+GC versus CC: OR = 1.15, 95%CI = 0.88–1.49). In the subgroup analysis by ethnicity, significant association was observed between TP53 codon72 polymorphism and male infertility risk in non‐Chinese (G versus C: OR = 1.47, 95%CI = 1.14–1.89), but not in Chinese population (G versus C: OR = 1.03, 95%CI = 0.87–1.22). In conclusion, this study suggested that TP53 codon72 polymorphism might be associated with an increased susceptibility to male infertility in non‐Chinese population, but not in Chinese population. Studies with larger sample sizes and representative population‐based cases and well‐matched controls are needed to validate our results.