Premium
Homocysteine, insulin‐like growth factor one and oestrogen levels in patients with erectile dysfunction‐associated chronic hepatitis C virus infection
Author(s) -
Abdelhamid Ahmed A.,
Sherief Mahmoud H.,
Nemr Nader A.,
Hassoba Howayda M.,
ElSakka Ahmed I.
Publication year - 2018
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13116
Subject(s) - medicine , homocysteine , erectile dysfunction , gastroenterology , risk factor , hepatitis c virus , chronic hepatitis , immunology , virus
We assessed the change of homocysteine (Hcy), insulin‐like growth factor one (IGF‐Ι) and oestrogen (E2) levels in patients with erectile dysfunction (ED) associated with chronic hepatitis C virus (HCV) infection. Eighty‐five male patients with chronic HCV and/or ED were enrolled in this study. Seventy‐five men were assigned to three equal groups ( n = 25/each); Group A: patients who had chronic HCV and ED. Group B: patients who had chronic HCV and had no ED complaint. Group C: patients who had ED with no chronic HCV. In addition to 10 control patients with no ED or chronic HCV (Group D). All patients were subjected to: detailed medical and sexual history, complete physical examination, laboratory assessment including measurement of serum Hcy, IGF‐1 and E2. The means of international index of erectile function scores were 8 and 16 in groups A and C respectively. There were significant differences in Hcy, IGF‐I and E2 among study groups ( p < 0.05 for each). There were significant differences in Hcy between patients with Child B and Child C. A strong association between severity of ED and chronic HCV was demonstrated. There was statistically significant increase of Hcy and E2 levels and reduction in IGF‐I level in patients with ED associated with chronic HCV infection.