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Ameliorative effect of resveratrol on testicular oxidative stress, spermatological parameters and DNA damage in glyphosate‐based herbicide‐exposed rats
Author(s) -
Avdatek F.,
Birdane Y. O.,
Türkmen R.,
Demirel H. H.
Publication year - 2018
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13036
Subject(s) - oxidative stress , resveratrol , dna damage , glyphosate , oxidative damage , chemistry , endocrinology , medicine , biology , andrology , pharmacology , dna , biochemistry , microbiology and biotechnology
Summary In this study, the reproductive impacts of being exposed to glyphosate ( GLF ) and the protective impacts of resveratrol ( RES ) were assessed in 28 Wistar male rats, which were equally separated into four groups. Control group were fed normal diet without GLF or RES , group II received normal feed containing 20 mg kg −1 daily −1 RES , group III received normal feed containing 375 mg kg −1 daily −1 GLF , and group IV received normal feed containing 375 mg kg −1 daily −1 GLF +20 mg kg −1 daily −1 RES . GLF administration decreased sperm motility, sperm plasma membrane integrity, glutathione level and superoxide dismutase in the testicular tissue of rats. On the other hand, abnormal sperm rate, malondialdehyde level, and DNA damage were detected to be high in the group treated with GLF . The findings indicate that RES protects spermatological parameters and DNA damage, decreases GLF ‐induced lipid peroxidation, improves the antioxidant defence mechanism and regenerates tissue damage in the testis of rats.