Premium
Application of lectin microarrays for the analysis of seminal plasma glycome
Author(s) -
Kołodziejczyk J.,
Blixt O.,
Olejnik B.,
Zimmer M.,
FerensSieczkowska M.
Publication year - 2018
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13018
Subject(s) - lectin , glycome , glycosylation , biology , semen , dna microarray , glycoprotein , glycan , immunology , genetics , gene , gene expression
Summary We report application of lectin microarrays, exploiting simultaneous interaction of seminal plasma samples with multiple lectins of different sugar specificities to compare the glycomes of fertile and infertile men. The results indicate reduced lectin reactivity associated with decreased fertility, especially affecting oligozoospermic subjects and probably O‐glycosylation. Lectin microarrays may become a potent tool for semen analysis in search of the association of glycosylation and male fertility.