Premium
Carnosine prevents testicular oxidative stress and advanced glycation end product formation in D‐galactose‐induced aged rats
Author(s) -
Aydın A. F.,
Küçükgergin C.,
Çoban J.,
DoğanEkici I.,
DoğruAbbasoğlu S.,
Uysal M.,
KoçakToker N.
Publication year - 2018
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12939
Subject(s) - glycation , oxidative stress , carnosine , galactose , chemistry , antioxidant , advanced glycation end product , ageing , reactive oxygen species , thiobarbituric acid , galactose oxidase , endocrinology , medicine , tbars , protein carbonylation , biochemistry , lipid peroxidation , receptor
Summary D‐Galactose is shown to mimic natural ageing in rodents by exacerbating oxidative stress and glycation. Steroid production and having a poor antioxidant system make testis vulnerable to galactose‐induced ageing. Antioxidation and antiglycating actions of carnosine may be intriguing for prevention of testicular ageing. In this study, male Wistar rats were applied D‐galactose (300 mg/kg; subcutaneously 5 days a week) and carnosine (250 mg/kg; intraperitoneally 5 days a week) along with D‐galactose for 2 months. D‐Galactose treatment increased testicular reactive oxygen species, thiobarbituric acid reactive substances, diene conjugates, protein carbonyls, advanced oxidation products of proteins and advanced glycation end products. Carnosine was capable of repelling oxidative stress and glycation produced by D‐galactose. Johnsen's score, which describes histopathological evaluation, was also significantly improved with preserved spermatogenesis by carnosine. It appears that carnosine deters the testicular oxidative stress due to galactose‐induced ageing directly by its antioxidative and antiglycating properties.