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Pentoxifylline mitigates detrimental impact of chronic nonbacterial prostatitis on sperm characteristics, reproductive hormones and histopathology in rats
Author(s) -
Yousefi S.,
Ahmadihamedani M.,
Narenji Sani R.,
Moslemi H. R.,
Ghafari Khaligh S.,
Darvishi M. M.
Publication year - 2018
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12932
Subject(s) - histopathology , prostatitis , medicine , sperm , hormone , endocrinology , malondialdehyde , testosterone (patch) , prostate , andrology , pathology , oxidative stress , cancer
Summary The protective role of pentoxifylline (PTX) on sperm characteristics, reproductive hormones and histopathology following carrageenan‐induced chronic nonbacterial prostatitis (CNP) was investigated in male Wistar rats. Thirty‐six rats were grouped into six rats per group. Group 1 (control) received saline normal. Group 2 received a single intraprostatic dose of 3% carrageenan (50 μl) on day 1 (CNP). Groups 3 and 5 received cernilton (standard drug) and PTX orally at 100 and 50 mg/kg for 14 consecutive days respectively. Groups 4 and 6 received a single dose of 3% carrageenan (50 μl) intraprostatically on day 1 followed by cernilton and PTX orally at 100 and 50 mg/kg on the eighth day for 14 consecutive days respectively. Prostatic index, serum prostatic specific antigen, malondialdehyde, testosterone and luteinising hormone levels were significantly increased ( p < .05), whereas serum follicle‐stimulating hormone, sperm count, motility and viability were significantly decreased ( p < .05) in CNP group. Histopathology of prostate revealed leucocyte infiltration, large involutions and projection into the lumen in CNP group and these aberrations were improved by PTX. According to these findings, we concluded that PTX effectively mitigated detrimental impact of CNP on sperm characteristics, reproductive hormones and histopathology in rats.