Cerium oxide nanoparticle elicits oxidative stress, endocrine imbalance and lowers sperm characteristics in testes of balb/c mice | Zendy

Adebayo O. A. | Zendy; Akinloye O. | Zendy; Adaramoye O. A. | Zendy

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Cerium oxide nanoparticle elicits oxidative stress, endocrine imbalance and lowers sperm characteristics in testes of balb/c mice

Author(s) -

Adebayo O. A.,

Akinloye O.,

Adaramoye O. A.

Publication year - 2018

Publication title -

andrologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.633

H-Index - 59

eISSN - 1439-0272

pISSN - 0303-4569

DOI - 10.1111/and.12920

Subject(s) - oxidative stress , endocrine system , sperm , balb/c , endocrinology , medicine , cerium oxide , andrology , chemistry , infertility , biology , hormone , oxide , immunology , pregnancy , genetics , immune system , organic chemistry

Summary The toxicity of metallic nanoparticles is a growing concern due to its application in industries and homes. We investigated the toxicity of cerium oxide nanoparticles (CeO 2 NP s) on reproductive system in male balb/c mice. Twenty mice were divided into four groups of five animals each and treated thus: normal saline (control), 100, 200 and 300 μg/kg CeO 2 NP s (i.p.,) thrice in a week for five consecutive weeks. Results showed that CeO 2 NP s significantly reduced the levels of haemoglobin, PCV and RBC count relative to controls. In addition, luteinising and follicle‐stimulating hormones ( FSH and LH ) and prolactin were significantly reduced in the mice. Specifically, CeO 2 NP s at 100 μg/kg decreased testosterone by 23%, while CeO 2 NP s at 200 μg/kg decreased FSH , LH and prolactin by 25%, 26% and 13%, respectively. Testicular malondialdehyde was increased by 103%, 106% and 135% in mice treated with 100, 200 and 300 μg/kg CeO 2 NP s, respectively. CeO 2 NP s caused a significant reduction in activities of antioxidant enzymes and levels of reduced glutathione and total nitric oxide. Moreso, CeO 2 NP s decreased sperm motility and count and increased total sperm abnormality in mice. Histology revealed congestion and degeneration of seminiferous tubules. Overall, CeO 2 NP s induces testicular dysfunction via disruption of antioxidant/oxidant balance and endocrine suppression.

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