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Oestradiol‐17β is a local factor inducing the early stage of spermatogenesis in mouse testes
Author(s) -
Kim K.G.,
Park Y. S.
Publication year - 2018
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.12905
Subject(s) - spermatogenesis , biology , meiosis , andrology , gene , testosterone (patch) , medicine , endocrinology , gene expression , stimulation , microbiology and biotechnology , genetics
Summary This study was undertaken to elucidate the effect of testicular oestradiol‐17β (E 2 ) on spermatogenesis. Spermatogonial development and spermatogenic gene expression in testicular germ cells were investigated using an in vitro culture system supplemented with E 2 . E 2 stimulated spermatocytogenic development of cultured testicular germ cells regardless of the addition of follicle‐stimulating hormone and testosterone to the culture medium. E 2 also induced the expression of genes encoding synaptonemal complex protein 1 and protamine 1, proteins required for spermatogenesis. In conclusion, the results of this study suggest that E 2 is a spermatocytogenic factor that acts via the stimulation of spermatogenic gene expression.